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APE
Adaptation des protozoaires à leur environnement
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Philippe GRELLIER |
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| Fonction |
Professeur , MNHN |
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01.40.79.35.10. |
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 Liste des publications 2002-2010
2010 |
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Spelman K, Depoix D, McCray M, Mouray E, and Grellier P. The traditional medicine Spilanthes acmella, and the alkylamides spilanthol and undeca-2 E -ene-8,10-diynoic acid isobutylamide, demonstrate in vitro and in vivo anti-malarial activity. 2010. Phytotherapy Research, in press. |
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Marti G, Eparvier V, Litaudon M, Grellier P, Guéritte F. 2010. A New Xanthone From the Bark Extract of / Rheedia Acuminata / and Antiplasmodial Activity of its Major Compounds. Molecules, 15:7106-14. |
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Madelaine C, Buriez O, Crousse B, Florent I, Grellier P, Retailleau P, Six Y. Aminocyclopropanes as precursors of endoperoxides with potential antimalarial activity: synthesis and biological evaluation. 2010. Org. Biomol. Chem., in press. |
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Marti G, Eparvier V, Moretti C, Prado S, Grellier P, Hue N, Thoison O, Delpech B, Guéritte F, Litaudon M. 2010. Antiplasmodial
benzophenone derivatives from the root barks of Symphonia
globulifer/a (Clusiaceae). Phytochemistry, 71:964-74.
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Duez S, Coudray L, Mouray E, Grellier P, Dubois J. 2010. Towards the synthesis of bisubstrate inhibitors of protein farnesyltransferase: synthesis and biological evaluation of new farnesylpyrophosphate analogues. Bioorg. Med. Chem. 18:543-56.
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Grellier P, Maroziene A, Nivinskas H, Sarlauskas J, Aliverti A, Cenas N. 2010. Antiplasmodial activity of quinones: roles of aziridinyl substituents and the inhibition of Plasmodium falciparum glutathione reducatase. Arch. Biochem. Biophys. 494:32-9.
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Albernaz LC, de Paula JE, Romero GA, Silva MD, Grellier P, Mambu L, Espindola LS. 2010. Investigation of plant extracts in traditional medicine of the Brazilian Cerrado against protozoans and yeasts. J Ethnopharmacol. 131:116-21. |
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Bourjot M, Apel C, Martin MT, Grellier P, Nguyen VH, Gueritte F, Litaudon M. 2010. Antiplasmodial, anti trypanosomal and cytotoxicity of prenylated flavonoids isolated from the stem bark of Artocarpus styracifolius. Planta Medica,
76:1600-4.
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Bastos I, Motta F, Charneau S, Santana J, Dubost L, Augustyns K, Grellier P. 2010. Prolyl Oligopeptidase of T rypanosoma brucei hydrolyzes native collagen, peptide hormones and is active in the plasma of infected mice. Microbes and Infection,
12:457-466.
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Berg M, Kohl L, Van der Veken P, Joossens J, Al-Salabi M, Castagna V, Giannese F, Cos P, Versées W, Steyaert J, Grellier P, Haemers A, Degano M, Maes L, de Koning L, Augustyns K. 2010. Evaluation of nucleoside hydrolase inhibitors for the treatment of African trypanosomiasis. Antimicrobial Agents and Chemotherapy,
54(5):1900-8.
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2009 |
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Demonchy R, Blisnick T, Deprez C, Toutirais G, Loussert C, Marande W, Grellier P, Bastin P, Kohl L. 2009. Kinesin 9 family members perform separate functions in motility and assembly of the trypanosome flagellum. J. Cell. Biol., 187:615-22. |
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Florent I, Setterblad B, Guillaume E, Da Silva C, Artiguenave F, Maréchal E, Brehelin L, Gascuel O, Wincker P, Grellier P. 2009. A Plasmodium falciparum FcB1-schizont-EST collection to study schizont specific gene structure and polymorphism. BMC genomics, 10: 235. |
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Henchiri H, Bodo B, Deville A, Dubost L, Zourgui L, Raies A, Grellier P, Mambu L. 2009. Sesquiterpenoids from Teucrium ramosissimum. Phytochemistry. 70:1435-41. |
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Marti G, Eparvier V, Moretti C, Susplugas S, Prado S, Grellier P, Retailleau P, Guéritte F, Litaudon M. 2009. Antiplasmodial guttiferones from the trunk latex of Moronobea coccinea (CLUSIACEAE). Phytochemistry. 70(1):75-85. |
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Paunescu E, Susplugas S, Boll E, Varga R, Mouray E, Grosu I, Grellier P, Melnyk P. 2009. Replacement of 4'-hydroxy group of Amodiaquine and Amopyroquine by aromatic and aliphatic substituants: Synthesis and Antimalarial Activity. ChemMedChem., 4 :549-61. |
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2008 |
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De Cian A, Grellier P, Mouray E, Depoix D, Monchaud D, Teulade-Fichou MP, Mergny JL, Alberti P. 2008. Plasmodium telomeric sequences: structure, stability and targeting by small compounds. ChemMedChem., 9(16):2730-9.
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Delarue-Cochin S., Paunescu E. Maes L., Mouray E., Sergheraert C., Grellier P., Melnyk P. 2008. Synthesis and antimalarial activity of new analogues of amodiaquine. Eur. J. Med Chem., 43 (2): 252-60 .
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Delarue-Cochin S, Grellier P, Maes L, Mouray E, Sergheraert C, Melnyk P. 2008. Synthesis and antimalarial activity of carbamate and amide derivatives of 4-anilinoquinoline. Eur J Med Chem.,
43(10):2045-55.
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Gnoatto SC, Susplugas S, Vechia LD, Ferreira TB, Dassonville-Klimpt A, Zimmer KR, Demailly C, Nascimento SD, Guillon J, Grellier P, Verli H, Gosmann G, Sonnet P. 2008. Pharmacomodulation on the 3-acetylursolic acid skeleton: Design, synthesis, and biological evaluation of novel N-{3-[4-(3-aminopropyl)piperazinyl]propyl}-3-O-acetylursolamide derivatives as antimalarial agents. Bioorg Med Chem., 16 : 771-82 .
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Grellier P, Depoix D, Schrével J, Florent I. 2008. Discovery of new targets for antimalarial chemotherapy. Parasite, 15:219-225.
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Grellier P , Nemeikaite-Ceniene A , Sarlauskas J , Cenas N . 2008. Role of single-electron oxidation potential and lipophilicity in the antiplasmodial in vitro activity of polyphenols: comparison to mammalian cells. Z Naturforsch . 63(5-6):445-50.
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Grellier P, Benach J, Labaied M, Charneau S, Gil H, Monsalve G, Alfonso R, Sawyer L, Lin L, Steiert M, Dupuis K. 2008. Photochemical inactivation with amotosalen and UVA light of Plasmodium and Babesia in platelets and plasma components. Transfusion, 48: 1676-1684.
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Guillon J, Moreau S, Mouray E, Sinou V, Forfar I, Belisle Fabre S, Desplat V, Millet P, Parzy D, Jarry C, Grellier P. New ferrocenic pyrrolo[1,2-a]quinoxaline derivatives: synthesis, and in vitro antimalarial activity. Bioorg Med Chem.,
16(20):9133-44.
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Mambu, L ., Grellier, P. Antimalarial compounds from traditionally-used medicinal plants. 2 nd edition « Bioactive Natural Products » Detection, Isolation and Structural Determination, Edited by S.M. Colegate and R.J. Molyneux, 2008 , pp 491-530.
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Paunescu E, Susplugas S, Boll E, Varga RA, Mouray E, Grellier P, Melnyk P. 2008. Synthesis and Antimalarial Activity of New Amino Analogues of Amodiaquine. Medicinal Chemistry, 4: 407- 425.
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Pham VC, Jossang A, Grellier P, Sévenet T, Nguyen VH, Bodo B. 2008. Structure and total synthesis of (-) myrionidine and (-)-schoberine, antimalarial alkaloids from Myrioneuron nutans. J. Org. Chem.,
3;73(19):7565-73.
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Ramanandraibe V, Grellier P, Martin MT, Deville A, Joyeau R, Ramanitrahasimbola D, Mouray E, Rasoanaivo P, Mambu L. 2008. Antiplasmodial Phenolic compounds from Piptadenia pervillei. Planta Med., 74: 417-421.
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Robert V, Bourgouin C, Depoix D, Thouvenot C, Lombard MN, Grellier P. 2008. Malaria and obesity: obese mice are resistant to cerebral malaria. Malar J. 2008 May 19;7:81. |
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2007 |
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Auffret G, Labaied M, Frappier F, Rasoanaivo P, Grellier P, Lewin G. 2007. Synthesis and antimalarial evaluation of a series of piperzinyl flavones. Bioorg. Med. Chem. Lett., 17: 959-963.
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Charneau S, Bastos IMD, Mouray E, Ribeiro BM, Santana JM, Grellier P, Florent I. 2007. Characterization of PfDYN2, a dynamine-like protein of Plasmodium falciparum expressed in schizonts. Microbes infect. 9: 797-805.
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de Mesquita ML, Grellier P, Mambu L, de Paula JE, Espíndola LS. 2007. In vitro antiplasmodial activity of brazilian Cerrado plants used as traditional remedies. J Ethnopharmacol., 110: 165-70.
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Mouray E, Moutiez M, Girault S, Sergheraert C, Florent I, Grellier P . 2007. Biochemical properties and cellular localization of Plasmodium falciparum protein disulfide isomerase. Biochimie, 89: 337-346.
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Nguyen-Pouplin J, Tran H, Tran H, Anh Phan T , Dolecek C, Farrar J, Hien Tran T, Caron P, Bodo B, Grellier P. 2007. Antimalarial and cytotoxic activities of ethnopharmacologically selected medicinal plants from south Vietnam . J. Ethnopharmacol., 109: 417-427. |
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2006 |
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Benoit-Vical F., Grellier P., Abdoulaye A., Moussa I., Ousmane A., Berry A., Ikhiri K and Poupat C. 2006. In vitro and in vivo antiplasmodial activity of Momordica balsamina alone or in a traditional mixture. Chemotherapy, 52:288-292. |
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Zmitek K, Stavber S, Zupan M, Bonnet-Delpon D, Charneau S, Grellier P, Iskra J. 2006. Synthesis and antimalarial activities of novel 3,3,6,6-tetraalkyl-1,2,4,5-tetraoxanes. Bioorg. Med. Chem.,
1;14(23):7790-5.
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Mambu L, Grellier P, Florent L, Ramanitrahasimbola D, Rasoanaivo P, Frappier F. 2006. Clerodane and labdane diterpenoids from Nuxia sphaerocephla. Phytochemistry 67:444-451.
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Krief S., Huffman M.A., Sévenet T., Hladik C-M., Grellier P., Loiseau P., Wrangham R.W. 2006. Bioactive properties of plants ingested by chimpanzees ( Pantroglodytes schweinfurthii ) in the Kibale National Park, Uganda. Am. J. Primatology 68:51-71.
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Melnyk P, Leroux V, Sergheraert C, Grellier P. 2006. Design, synthesis and in vitro antimalarial activity of an acylhydrazone library. Bioorg Med Chem Lett. 16:31-5. |
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2005 |
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Guillon J, Moreau S, Massip S, Sonnet P, Forfar-Bares I, Leger J-M, Grellier P , Jarry C. 2005. Crystal structure of Bis{N-(pyrrolo [1,2-a] quinoxalin-4-yl)-3-aminopropyl}piperazine. Analytical Sciences : X-Ray Structure Analysis online, 21:209-210. |
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Laundry de Mesquita M., Desrivot J., Bories C., Fournet A., Elias de Paula J., Grellier P. and Salmen Espinola L. 2005. Antileishmanial and trypanocidal activity of Brazilian Cerrado plants. Mem. Inst. Oswaldo Cruz. 100:783-787. |
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Ryckebusch A , Gilleron P , Millet R , Houssin R , Lemoine A , Pommery N , Grellier P, Sergheraert C , Henichart JP . 2005. Novel N-(4-Piperidinyl)benzamide Antimalarials with Mammalian Protein Farnesyltransferase Inhibitory Activity. Chem Pharm Bull ( Tokyo ) 53:1324-6. |
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Fernandes LC , Bastos IM , Lauria-Pires L , Rosa AC , Teixeira AR , Grellier P, Schrevel J , Santana JM . 2005. Specific human antibodies do not inhibit Trypanosoma cruzi oligopeptidase B and cathepsin B, and immunoglobulin G enhances the activity of trypomastigote-secreted oligopeptidase B. Microbes Infect. 7:375-84. |
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Laundry de Mesquita M., Grellier P. , Blond A., Brouard J.-P., Elias de Paula J., Salmen Espinola L. and Mambu L. 2005. New ether diglycosides from Matayba guianensis with antiplasmodial activity. Bioorg. Med. Chem 13:4499-4503. |
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Ramanandraibe V, Martin M-T, Rakotondramananana D, Mambu L, Ramanitrahasimbola D, Labaïed M , Grellier P, Rasoanaivo P and Frappier F. Pseudoguaianolide sesquiterpene lactones from Vernoniopsis caudata and their antiplasmodial activities. J. Nat Prod. 68:800-803. |
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Zhiri N.G., Grellier P., Guédé-Gunia F., Bodo B. and Mambu L. 2005. Isolation, characterization and antiplasmodial activity of steroidal alkaloids from Funtumia elastica (Preuss) Stapf. Bioorg Med Chem Lett , 15:2637-2640. |
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Zirihi N.G., Mambu L., Guédé-Guina F., Bodo B. and Grellier P . 2005. In vitro antiplasmodial activity and cytotoxicity upon mammalian cells of thirty three plants used in west tropical Africa for treatment of malaria. J. Ethnopharmacol . 98 :281-285. |
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Ryckebusch A., Deprez-Poulain R., Debreu-Fontaine M.-A., Mouray E., Grellier P. , Sergheraert C. and Melnyk P. 2005. Synthesis and antimalarial evaluation of new N1-(7-chloro-4-quinolyl)-1,4-bis(3-aminopropyl)piperazine derivatives. Bioorg Med Chem Lett. 2005 15(2):297-302 |
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Grellepois F., Grellier P., Bonnet-Delpon D. and Bégué J-P. Design, Synthesis and Antimalarial Activity of CF3-Mefloquine Dual Molecules. ChemBioChem . 6 :648-652. |
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Bastos I.M.D., Grellier P. , Martins N.F., Cadavid-Restrepo G., de Souza-Ault M.R., Augustyns K., Teixeira A.R.L., Schrével J., Maigret B., da Silveira J.F. and Santana J. 2004. Molecular, functional and structural properties of the prolyl oligopeptidase of Trypanosoma cruzi (POP Tc80) that is required for parasite entry into mammalian cells. Biochem. J . 388:29-38.
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2004 |
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Labaied M., Dagan A., Dellinger M., Geze M., Egee S., Thomas S.L., Wang C., Gatt S. And Grellier P. 2004. Anti- Plasmodium activity of ceramide analogs. Malaria J. 3:49. |
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Rasoanaivoi P, Ramanitrahasimbola D, Rafatro H, Rakotondramanana D, Robijaona B, Rakotozafy A, Ratsomamanga-Urverg S, Labaied M, Grellier P., Allorge L., Mambu L and Frappier F. 2004. Screening extracts of Madagascan plants in search of antiplasmodial compounds. Phytother Res. 18: 742-747 |
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Hay AE, Hélesbeux JJ, Duval O, Labaied M, Grellier P and Richomme P. 2004. Antimalarial xanthones from Calophyllum caledonicum and Garcinia vieillardii . Life Sci. 75 :3077-3085. |
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Frédérich M., Tits M., Goffin E., Philippe G., Grellier P . , De Moi P., Hayette M.-P. and Angenot L. 2004. In vitro and in vivo antimalarial properties of isostrychnopentamine, an indolomonoterpenic alkaloid from Strychnos usambarensis . Planta Med. 70 :520-525. |
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Ryckebusch A., Fruchart J.-S., Cattiaux L., Rousselot-Paillet P., Leroux V., Melnyk O., Grellier P., Mouray E., Sergheraert C. and Melnyck P. 2004. Design, synthesis and antimalarial activity of a glyoxylylhydrazone library. Bioorganic & Medicinal Chemistry Letters 14 : 4439-4443. |
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Krief S, Kasenene J., Grellier P , Martin M-T and Sévenet T. 2004. Novel antimalarial compounds isolated after the survey of self-medicative behavior of wild chimpanzees in Uganda . Antimicrobial Agents Chemother. 48:3196-9. |
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Guillon J, Grellier P , Labaied M, Sonnet P, Léger J-M, Déprez-Poulain R, Forfar-Bares I, Dallemagne P, Lemaître N, Péhourcq F, Rochette J, Sergheraert C and Jarry C. Synthesis, Antimalarial Activity and Molecular Modeling of New Pyrrolo [1,2- a ] quinoxalines, Bispyrrolo [1,2- a ] quinoxalines, Bis pyrido [3,2- e ] pyrrolo [1,2- a ] pyrazines and Bispyrrolo [1,2- a ] thieno [3,2- e ] pyrazine. 2004. J. Med Chem . 47(8): 1997-2009. |
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Okpekon T, Yolou S., Gleye C., Loiseau P., Bories C., Grellier P. , Frappier F., Laurens A. Hocquemiller R. 2004. Antiparasitic activities of medicinal plants used in Ivory Coast . J. Ethnopharmacol . 90 :91-97.
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Magueur G., Crousse B., Charneau S., Grellier P., Bégué J.-P. and Bonnet-Delpon D. 2004. Fluoro-Artemisinin : trifluoromethyl analog of artemether. J. Med. Chem. , 47 :2694-9.
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Grellepois F, Chorki F, Ourévitch M, Charneau S, Grellier P, McIntosh KA, Charman WN, Pradines B, Crousse B, Bonnet-Delpon D and Bégué JP. 2004. Orally Active Antimalarials : Hydrolytically Stable Derivatives of 10-Trifluoromethyl Anhydrodihydroartemisinin. J. Med. Chem., 47 :1423-33.
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Florent I., Charneau S., Grellier P. 2004. Plasmodium falciparum genes differentially expressed during merozoite morphogenesis. Mol. Biochem. Parasitol., 135 :143-148. |
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2003 |
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Beldjoudi N., Mambu L., Labaïed M., Grellier P. , Rasoanaivo P., Frappier F. 2003. Flavonoids from Dalbergia louvelii and their antiplasmodial activity. J. Nat. Prod. 66 :1441-1450. |
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Biot C, Dessolin J, Grellier P ., Davioud-Charvet E. 2003. Double-drug development against antioxidant enzymes from Plasmodium falciparum. Redox Rep . 8 :280-283. |
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Bal G., Van der Veken P., Antonov D., Lambeir A-M, Grellier P., Croft S., Augustyns K., Haemers A. 2003 Prolylisoxazoles: potent inhibitors of prolyloligopeptidase with antitrypanosomal activity . Biorganic & Medicinal Chemistry Letters , 13 :2875-2878.
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Flipo M., Florent I., Grellier P., Sergheraert C., Deprez-Poulain R. 2003 Design, synthesis and antimalarial activity of novel, quinoline based, zinc metalloprotease inhibitors. Biorganic &Medicinal Chemistry Letters , 13 : 2659-2662.
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Ryckebusch, A., Deprez-Poulain, R., Maes, L., Debreu-Fontaine, M. A., Mouray, E., Grellier, P., Sergheraert, C. 2003. Synthesis and in Vitro and in Vivo Antimalarial Activity of N(1)-(7- Chloro-4-quinolyl)-1,4-bis(3-aminopropyl)piperazine Derivatives. J. Med. Chem . 46(4) :542-557.
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Ryckebusch, A., Deprez-Poulain, R., Debreu-Fontaine, M. A., Richard Vandaele, Mouray, E., Grellier, P. and Sergheraert, C. 2003. Synthesis and Antimalarial Evaluation of new 1,4-bis(3-aminopropyl)piperazine Derivatives. Bioorganic & Medicinal Chemistry Letters. 13 , 3783-3787. |
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2002 |
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Helesbeux J.-J., Peyronnet D., Labaied M., Grellier P. , Frappier F., Seraphin D., Richomme P., Duval O. 2002. Synthesis and Antimalarial activity of some new 1,2-dioxolane derivatives. Journal of Enzyme Inhibition and Medicinal Chemistry , 17 : 431-437.
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Ryckebusch, A., Deprez-Poulain, R., Debreu-Fontaine, M., Vandaele, R., Mouray, E., Grellier, P., Sergheraert, C. 2002. Parallel synthesis and anti-malarial activity of a sulfonamide library. Bioorg. Med. Chem. Lett. 12 : 2595-2598. |
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Akendengué B., Ngou-Milama E., Roblot F., Laurens A., Hocquemiller R., Grellier P., Frappier F. 2002. Antiplasmodial activity of Uvaria klaineana (Annonaceae). Planta Med. 68 : 167-169. |
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Vendeville S., Goossens F., Debreu-Fontaine M.-A., Landry V., Davioud-Charvet E., Grellier P., Scharpe, S., Sergheraert C. 2002. Comparison of the inhibition of human and Trypanosoma cruzi prolyl oligopeptidases. Bioorg Med Chem. 10 :1719-1729.
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Mambu L., Ramanandraibe V., Martin M.-T., Blond A., Grellier P. and Frappier F. 2002. Constituents of Burasaïa madagascarensis : a New Clerodane Type Diterpene. Planta Med . 68 : 377-379. |
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2001 |
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Grellier P. , Vendeville S., Joyeau R., Drobecq H., Frappier F., Teixeira A.R.L., Schrével J., Davioud-Charvet E., Sergheraert C., Santana J. 2001. Trypanosoma cruzi prolyl oligopeptidase Tc80 is involved in non-phagocytic mammalian cell in by trypomastigotes. J. Biol. Chem. 276 : 47078-86 |
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Davioud-Charvet E., Delarue S., Biot C., Schwöbel B., Boehme C.C., Müssigbrodt A., Maes L., Sergheraert C., Grellier P. , Schirmer R.H., Becker K. 2001. A prodrug form of a Plasmodium falciparum glutathione reductase inhibitor conjugated with a 4-anilinoquinoline. J. Med. Chem . 44 :4268-4276. |
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Delarue S., Girault S., Dali Ali F., Maes L., Grellier P. , Sergheraert C. 2001. « One pot » synthesis and antimalarial activity of formamidine derivatives of amodiaquine. Chem. Pharm. Bull. 48 : 933-937. |
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Grellier P. , Sarlauskas J., Anusevicius Z, Maroziene A., Houee-Levin C., Schrevel J., Cenas N. 2001. Antiplasmodial activity of nitroaromatic and quinoidal compounds : redox potential vs inhibition of erythrocyte glutathione reductase. Accepted for publication Arch. Bioch. Biophys . 393(2) : 199-206. |
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Delarue S., Girault S., Maes L., Debreu-Fontaine M.-A., Labaeïd M., Grellier P., Sergheraert C. 2001. Synthesis, in vitro and in vivo antimalarial activity of new 4-anilinoquinolines. J. Med. Chem. 44 : 2827-2833. |
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Girault S., Grellier P., Berecibar A., Maes L., Lemière P., Mouray E., Davioud-Charvet E., Sergheraert C. 2001. Antiplasmodial activity and cytotoxicity of bis-, tris-, and tetraquinolines with linear or cyclic amino linkers. J. Med. Chem . 44 : 1658-1665. |
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Girault, S., Delarue, S., Grellier, P ., Bérécibar, A., Maes, L., Quiirijnen, L., Lemière, P., Debreu-Fontaine, M.A., Sergheraert, C. 2001. Antimalarial in-vivo activity of bis(9-amino-6-chloro-2-methoxy)acridines. J. Pharm. Pharmacol. 53 : 935-938.
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Arzel A., Rocca P., Grellier P. , Labaeïd M., Frappier F., Guéritte F., Gaspard C., Marsais F., Godard A., Quéguiner G. 2001. New synthesis of benzo-delta-carbolines, cryptolepines, and their salts. In vitro cytotoxicity, antimalarial and antitrypanosomal activities of delta-carbolines and benzo-delta-carbolines. J. Med Chem. 44 : 949-960.
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2000 |
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Florent I., Mouray E., Fouad Dali A., Drobecq H., Girault S., Schrével J., Sergheraert C., Grellier P. 2000. Cloning of Plasmodium falciparum protein disulfide isomerase homologue by affinity purification by using the antiplasmodial inhibitor 1,4-bis{3- [ N -(cyclohexyl methyl)amino] propyl} piperazine. FEBS Letters 484 : 246-252.
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Girault S., Grellier P., Berecibar A., Maes L., Mouray E., Lemière P., Debreu M.-A., Davioud-Charvet E., Sergheraert C. 2000. Antimalarial, Antitrypanosomal, Antileishmanial Activities and Cytotoxicity of Bis(9-amino-6-chloro-2-methoxyacridines): Influence of the Linker. J. Med Chem. 43 :2646-2654. |
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Knockaert M., Gray N., Damiens E., Grellier P ., Grant K., Fergusson D., Mottram J., Soete M., Dubremetz J.-F., Le Roch K., Doerig C., Schultz P.G., Meijer L. 2000. Intracellular targets of cyclin-dependent kinase inhibitors : identification by affinity chromatography on immobilised inhibitors. Chem. Biol. 7 :411-422.
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Joyeau R., Maoulida C., Guillet C., Frappier F. , Teixeira A.R.L. , Schrével J., Santana J., Grellier P. 2000. Synthesis and Activity of Pyrrolidinyl- and Thiazoldinyl-Dipeptides Derivatives as Inhibitors of the Tc80 Prolyl Oligopeptidase from Trypanosoma cruzi . Eur. J. Med. Chem. 35 : 257-266. |
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1999 |
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LeBonniec S., Deregnaucourt C., Redeker V., Banerjee R., Grellier P ., Goldberg D.E., Schrével J. 1999. Plasmepsin II, an acidic hemoglobinase from the Plasmodium falciparum food vacuole, is active at neutral pH on the host erythrocyte membrane skeleton. J. Biol. Chem. 274 :14218-14223.
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Vendeville S., Bourel L., Davioud-Charvet E., Grellier P. , Deprez B., Sergheraert C. 1999. Automated parallel synthesis of a tetrahydroisoquinolin-based library : potential prolyl endopeptidase inhibitors. Bioorg. Med. Chem. Lett. 9 : 437-442. |
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Grellier P. , Blum J.., Santana J., Bylène E., Mouray E., Sinou V., Teixeira A.R.L., Schrével J. 1999. Involvement of calyculin A-sensitive phosphatase(s) in the differentiation of Trypanosoma cruzi trypomastigotes to amastigotes. Mol. Biochem. Parasitol . 98 (2):239-252. |
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Grellier P ., Sinou V., Garrault de Loubresse N., Bylèn E., Boulard Y., Schrével J. 1999. Selective and reversible effects of vinca alkaloids on Trypanosoma cruzi epimastigote forms : blockage of cytokinesis without inhibition of the organelle duplication. Cell Motil. & Cytoskeleton , 42 :36-47.
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Vendeville S., Buisine E., Williard X., Schrével J., Grellier P ., Santana J., Sergheraert C. 1999. Identification and synthesis of inhibitors of an 80 kDa protease from Trypanosoma cruzi through the screening of a combinatorial peptide library. Chem. Pharma. Bull . 47 :194-199. |
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1998 |
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Sinou V., Boulard Y., Grellier P., Schrével J. 1998. Host cell and malarial targets for Docetaxel (Taxotere R ) during the erythrocytic development of Plasmodium falciparum. J. Euk. Microbiol. 45 :171-183.
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Carvalhaes M.S., De Toledo Nobrega O., Aragao J.B. Grellier P., Santana J., Schrével J., Teixeira A.R.L. 1998. Chemotherapy of experimental Trypanosoma cruzi infection with specific IgG-chlorambucil conjugate. Lab. Investigation 78 : 707-714. |
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Santus R., Grellier P., Schrével J., Mazière J.-C., Stoltz J.-F. 1998. Photodecontamination of blood components : advantages and drawbacks. Clin. Hemorheol. Microcircul. 18 :299-308. |
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1997 |
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Grellier P., Santus R., Mouray I., Agmon V., Mazière J.-C., Rigomier D., Dagan A., Gatt S., Schrével J. 1997. Photosensitized inactivation of Plasmodium falciparum and Babesia divergens -infected erythrocytes in whole blood by lipophilic pheophorbide derivatives. Vox Sang . 72 : 211-220.
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Santana J., Grellier P., Schrével J., Teixeira A.R.L. 1997. Trypanosoma cruzi 80 kDa proteinase with specificity to collagen I and IV, . Biochem. J. 324 :129-137. |
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1996 |
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Grellier P. , Frappier F., Trigalo F., Ramiaramanana L., Millerioux V., Deharo E., Bodo B., Schrével J., Pousset J.L. 1996. Antimalarial activity of alkaloids isolated from Cryptolepis sanguinolenta , cryptolepine and isocryptolepine . Phytotherapy Res. 10 : 317-321.
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Sinou V., Grellier P., Schrével J. 1996. In vitro and in vivo inhibition of erythrocytic development of malarial parasites by docetaxel (Taxotere). Antimicrob. Agents Chemother. 40 : 358-361. |
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Frappier F., Jossang A., Soudon J., Calvo F., Rasoanaivo P., Ratsimamanga-Urverg S., Saez J., Schrével J., Grellier P. 1996. Bisbenzylisoquinolines as modulators of chloroquinoresistance in Plamodium falciparum and MDR in tumor cell . Antimicrob. Agents Chemother . 40 : 1476-1481. |
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Le Bonniec S., Fournier C., Deregnaucourt C., Grellier P. , Dhermy D., Lecomte M.-C., Schrével J. 1996. Human erythroid spectrin a subunit and its SH3 domain are sensitive to acidic Plasmodium falciparum proteolytic activity. C.R. Acad. Sci. Paris 319 : 1011-1017.
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Schrével J., Millerioux V., Sinou V., Frappier F., Santus R, Grellier P. 1996. New trends in chemoterapy on human and animal blood parasites . Parasitol. Res. 82 : 283-284. |
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1994 |
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Carcy B., Bonnefoy S., Guillote M., Le Scanf C., Grellier P ., Schrével J., Fandeur T., Mercereau-Puijalon O. 1994. A large polygenic family expressed during the erythrocytic schizogony of Plasmodium falciparum . Mol. Biochem. Parasitol. 68 : 221-233.
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Florent I., Le Bonniec S., Carcy B., Grellier P. , Mercereau-Puijalon O., Bonnefoy S., Dhermy D., Monsigny M., Mayer R., Schrével J. 1994. Plasmodium falciparum proteinase: cloning of the putative gene coding for the merozoite proteinase for erythrocyte invasion (MPEI) and determination of hydrolysis sites of spectrin by Pf37 proteinase. Mem. Inst. Oswaldo Cruz. 89 : 45-47. |
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Grellier P., Précigout E., Valentin A., Carcy B., Schrével J. 1994. Characterization of a new 60 kDa rhoptry protein of Plasmodium falciparum expressed in late schizogony. Biol. Cell. 82 : 129-138. |
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Tudge C.C., Grellier P. Justine J.-L. 1994. Actin in the acrosome of the spermatozoa of the crab, Cancer Pagurus L. (Decapoda, Crustacea). Mol. Reprod. Dev. 38 : 178-186. |
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Grellier P ., Valentin A., millerioux V., Schrével J., Rigomier D. 1994. Inhibition of the intraerythrocytic development of Plasmodium falciparum and Babesia divergens by HMG-CoA reductase inhibitors. Antimicrob. Agents Chemother. 38 : 1144-1148.
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Schrével J., Sinou V., Grellier P ., Frappier F., Guénard D., Potier P.1994. Interaction between docetaxel (Taxotere) and Plasmodium falciparum -infected erythrocytes. Proc. Natl. Acad. Sci. USA 91 : 8472-8476. |
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1992-1993 |
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Schrével J., Barrault C., Deguercy A., Grellier P., Lawton P., Heidrich H.G., Caballero M., Monsigny M., Mayer R. 1993. Plasmodium falciparum proteinases and red blood cell invasion. Parassitologia 35 , 103-105
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Schrével J., Grellier P., Rigomier D. 1992. New approaches in in vitro cultures of Plasmodium falciparum and Babesia divergens by using serum-free medium. Mem.Inst. Oswaldo Cruz. 87 : 71-75. |
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Santana J.M., Grellier P. , Rodier M.H., Schrével J., Teixeira A. 1992. Purification and characterization of a new 120 kDa alkaline proteinase of Trypanosoma cruzi . Biochem. Biophys. Res. Commun. 187 : 1466-1473. |
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1991 |
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Grellier P ., Rigomier D., Clavey V., Fruchard J.C., Schrével J. 1991. Lipid traffic between high density lipoproteins and the Plasmodium falciparum infected red blood cells. J. Cell Biol. 112 : 267-277. -
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Schrével J., Barrault C., Grellier P., Mayer R., Monsigny M. 1991. Plasmodium proteinases during the erythrocytic phase in malaria. In : "Biochemical Protozoology" (G.Coombs and M.North eds). Taylor and Francis, London , pp270-280. |
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Jakobsen P., Grellier P ., Theander T.G., Behrendt N., Torii M., Aikawa M.,Schrével J., Jepsen S. 1991. Identification and localization of a soluble antigen, Ag2, of 136 kDa from Plasmodium falciparum in vitro cultures. Acta Pathol. Microbiol. Immunol. Scand.(APMIS) 99 : 155-162. |
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Mayer R., Picard I. , Lawton P., Grellier P., Barrault C., Monsigny M., Schrével J. 1991. Peptide derivatives specific for a Plasmodium falciparum proteinase inhibit the human erythrocyte invasion by merozoite. J. Med. Chem. 34 : 3029-3035. |
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Lawton P., Barrault C., Grellier P., Schrével J., Heidrich H.G. 1991. The native form of the Plasmodium falciparum Pf68 neutral proteinase is an Mr 105,000 polypeptide. Parasitol. Res. 77 : 720-722. |
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Gallo J.M., Escalier D., Grellier P. , Précigout E., Albert M., David G., Schrével J. 1991. Characterization of a monoclonal antibody to human proacrosin and its use in acrosomal status evaluation. J. Histochem. Cytochem. 39 : 273-282. |
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Jakobsen P., Hviid L., Theander T.G., Riley E.M., Grellier P. , Bruun L.S., Dalsgaard K., Schrével J., Jepsen S. 1991. Isolation and characterization of a soluble antigen complex of Plasmodium falciparum with pyrogenic properties. Acta Pathol. Microbiol. Immunol. Scand. (APMIS) 99: 21-29.
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1987-1990 |
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Grellier P., Rigomier D., Schrével J. 1990. Induction in vitro de la schizogonie de Plasmodium falciparum par les lipoprotéines humaines de haute densité (HDL). C.R. Acad. Sci. Paris 311 : 361-367. |
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Jakobsen P., Jepsen S., Riley E.M., Theander T.G., Grellier P., Lihme A., Hviid I., Dziegiel M., Schrével J. 1990. Biochemical characterization, localization and immunostimulating properties of a soluble glycoprotein, Ag1, isolated from in vitro cultures of Plasmodium falciparum. Parasitol Res. 76 : 657-661.
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Grellier P., Picard I. , Bernard F., Mayer R., Heidrich H.G., Monsigny M., Schrével J. 1989. Purification and characterization of a Plasmodium falciparum neutral endopeptidase: identification in purified merozoites. Parasitol Res. 75 : 455-460. |
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Schrével J., Grellier P., Mayer M., Monsigny M. 1988. Neutral proteases involved in the reinvasion of erythrocytes by Plasmodium merozoites. Biol. Cell. 64 : 233-245. |
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Mayer R., Picard I., Bernard F., Lawton P., Grellier P., Schrével J., Monsigny M.1987. Peptide derivatives specific for a Plasmodium falciparum protease involved in red blood cell invasion by merozoites. Peptide Chemistry and Biology , 662-663. |
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