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APE
Adaptation des protozoaires à leur environnement
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Isabelle FLORENT |
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Maître de conférences, MNHN |
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01.40.79.35.47. |
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 Liste des publications
2011 |
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Grellier P, Deregnaucourt C, Florent I. Advances in antimalarial drug evaluation and new targets for antimalarials. In "Malaria Parasites", ISBN 979-953-307-072-7, february 2012. |
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Travers MA, Florent I, Kohl L, Grellier P. Probiotics for the controls of parasites : an overview. 2011. J. Parasitol. Res.
2011:610769 |
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2010 |
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Florent I, Maréchal E, Gascuel O and Bréhélin L. Bioinformatic strategies to provide functional clues to the unknown genes in Plasmodium falciparum genome. 2010. Parasite,Dec;17(4):273-83. |
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Madelaine C, Buriez O, Crousse B, Florent I, Grellier P, Retailleau P, Six Y. Aminocyclopropanes as precursors of endoperoxides with potential antimalarial activity : synthesis and biological evaluation. 2010. Org. Biomol. Chem.,
Dec 21;8(24):5591-601. |
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Azimzadeh O, Sow C, Gèze M, Nyalwidhe J, Florent I. Plasmodium falciparum PfA-M1 aminopeptidase is trafficked via the parasitophorous vacuole and marginally delivered to the food vacuole. 2010. Malaria Journal, 9(1):189. |
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Brehelin L, Florent I, Gascuel O, Marechal E. Assessing functional annotation transfers with inter-species conserved coexpression : application to Plasmodium falciparum. 2010. BMC Genomics, 11:35. |
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2009 |
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Florent I, Porcell BM, Guillaume E, Da Silva C, Artiguenave F, Maréchal E, Bréhélin L, Gascuel O, Charneau S, Wincker P, Grellier P. A Plasmodium falciparum FcB1-schizont-EST collection providing clues to schizont specific genes structure and polymorphism. BMC Genomics, May 2009, 10:235. |
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2008 |
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Grellier P, Depoix D, Schrével J, Florent I. Discovery of new targets for antimalarial chemotherapy. Parasite. 2008 Sept;15(3):219-225. |
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Depoix D , Kohl L, Florent I. L'analyse fonctionnelle des gènes chez les protozoaires parasites. Biofutur. 2008 vol 27/289 : 46-51.
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Razakantoanina V, Florent I, Jaureguiberry G. Plasmodium falciparum : functional mitochondrial ADP/ATP transporter in Escherichia coli plasmic membrane as a tool for selective drug screening. Experimental Parasitology (2008), 118 (2): 181-7.
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2007 |
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Charneau S, Bastos IM, Mouray E, Ribeiro BM, Santana JM, Grellier P, Florent I. Characterization of PfDYN2, a dynamin-like protein of Plasmodium falciparum expressed in schizonts. Microbes and Infection (2007), 9 (7): 797-805.
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Flipo M, Beghyn T, Leroux V, Florent I, Deprez BP, Deprez-Poulain RF. Novel selective inhibitors of the zinc plasmodial aminopeptidase PfA-M1 as potential antimalarial agents. Journal of Medicinal Chemistry (2007), 50 (6): 1322-34. |
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Mouray E, Moutiez M, Girault S, Sergheraert C, Florent I and Grellier P. Biochemical properties and intracellular localization of Plasmodium falciparum protein disulfide isomerase. Biochimie (2007), 89 (3): 337-46. |
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2005 |
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Florent I, Lecaille F, Montagne J-J, Gauthier F, Schrével J and Lalmanach G. Labelling of four distinct trophozoite falcipains of Plasmodium falciparum by a cystatin-derived probe. Biological Chemistry (2005), 386: 401-406. |
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2004 |
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Florent I, Charneau S and Grellier P. Plasmodium falciparum genes differentially expressed during the merozoite morphogenesis. Molecular and Biochemical Parasitology (2004), 135: 143-148. |
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2003 |
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Flipo M, Florent I, Grellier P, Sergheraert C and Poulain R. Design, synthesis and antimalarial activity of novel, quinoline-based, zinc metalloprotease inhibitors. Bioorganic and Medicinal Chemistry Letters (2003), 13: 2659-2662. |
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2002 |
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Allary M, Schrével J and Florent I. Properties, stage-dependent expression and localization of Plasmodium falciparum M1 family zinc-aminopeptidase. Parasitology (2002), 125: 1-10. |
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2000 |
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Florent I, Mouray E, Dali Ali F, Drobecq H, Girault S, Schrével J, Sergheraert C and Grellier P. Cloning of Plasmodium falciparum protein disulfide isomerase homologue by affinity purification using the antiplasmodial inhibitor inhibitor 1,4-bis{3- [ N -(cyclohexyl methyl)amino] propyl}piperazine. FEBS Letters (2000), 484: 246-252. |
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1998 |
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Florent I, Derhy Z, Allary M, Monsigny M, Mayer R and Schrével J. A Plasmodium falciparum aminopeptidase gene belonging to the M1 family of zinc-metallopepidases is expressed in erythrocytic stages. Molecular and Biochemical Parasitology (1998) 97, 149-160. |
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1994 |
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Florent I, Bonniec S, Carcy B, Grellier P, Mercereau-Puijalon O, Bonnefoy S, Dhermy D, Monsigny M, Mayer R and Schrével J. Plasmodium falciparum proteinases : cloning of the putative gene coding for the merozoite proteinase for erythrocyte invasion (MPEI) and determination of hydrolysis sites of spectrin by Pf37 proteinase. Mémorias do Instituto Oswaldo Cruz (1994) 89, 47-49. |
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1991 |
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Ross D, Raibaud A, Florent I, Sather S, Gross MK, Storm DR and Eisen H. The trypanosomes VSG expression site encodes adenylate cyclase and a leucine-rich putative regulatory gene. EMBO Journal (1991), 10: 2047-2053. |
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Florent I, Raibaud A and Eisen H. A family of genes related to a new Expression Site-Associated Gene in Trypanosoma equiperdum . Molecular and Cellular Biology (1991), 11: 2180-2188. |
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1987 |
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.Florent I, Raibaud A, Baltz T and Eisen H. On the role of the repeated sequences 5' to variant surface glycoprotein genes in african trypanosomes. Gene (1987) 53 pp 55-62. |
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